1. Bence Jones Proteins found in urine occur in:





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MCQ->Bence Jones Proteins found in urine occur in:....
MCQ-> Cells are the ultimate multi-taskers: they can switch on genes and carry out their orders, talk to each other, divide in two, and much more, all at the same time. But they couldn’t do any of these tricks without a power source to generate movement. The inside of a cell bustles with more traffic than Delhi roads, and, like all vehicles, the cell’s moving parts need engines. Physicists and biologists have looked ‘under the hood’ of the cell and laid out the nuts and bolts of molecular engines.The ability of such engines to convert chemical energy into motion is the envy nanotechnology researchers looking for ways to power molecule-sized devices. Medical researchers also want to understand how these engines work. Because these molecules are essential for cell division, scientists hope to shut down the rampant growth of cancer cells by deactivating certain motors. Improving motor-driven transport in nerve cells may also be helpful for treating diseases such as Alzheimer’s, Parkinson’s or ALS, also known as Lou Gehrig’s disease.We wouldn’t make it far in life without motor proteins. Our muscles wouldn’t contract. We couldn’t grow, because the growth process requires cells to duplicate their machinery and pull the copies apart. And our genes would be silent without the services of messenger RNA, which carries genetic instructions over to the cell’s protein-making factories. The movements that make these cellular activities possible occur along a complex network of threadlike fibers, or polymers, along which bundles of molecules travel like trams. The engines that power the cell’s freight are three families of proteins, called myosin, kinesin and dynein. For fuel, these proteins burn molecules of ATP, which cells make when they break down the carbohydrates and fats from the foods we eat. The energy from burning ATP causes changes in the proteins’ shape that allow them to heave themselves along the polymer track. The results are impressive: In one second, these molecules can travel between 50 and 100 times their own diameter. If a car with a five-foot-wide engine were as efficient, it would travel 170 to 340 kilometres per hour.Ronald Vale, a researcher at the Howard Hughes Medical Institute and the University of California at San Francisco, and Ronald Milligan of the Scripps Research Institute have realized a long-awaited goal by reconstructing the process by which myosin and kinesin move, almost down to the atom. The dynein motor, on the other hand, is still poorly understood. Myosin molecules, best known for their role in muscle contraction, form chains that lie between filaments of another protein called actin. Each myosin molecule has a tiny head that pokes out from the chain like oars from a canoe. Just as rowers propel their boat by stroking their oars through the water, the myosin molecules stick their heads into the actin and hoist themselves forward along the filament. While myosin moves along in short strokes, its cousin kinesin walks steadily along a different type of filament called a microtubule. Instead of using a projecting head as a lever, kinesin walks on two ‘legs’. Based on these differences, researchers used to think that myosin and kinesin were virtually unrelated. But newly discovered similarities in the motors’ ATP-processing machinery now suggest that they share a common ancestor — molecule. At this point, scientists can only speculate as to what type of primitive cell-like structure this ancestor occupied as it learned to burn ATP and use the energy to change shape. “We’ll never really know, because we can’t dig up the remains of ancient proteins, but that was probably a big evolutionary leap,” says Vale.On a slightly larger scale, loner cells like sperm or infectious bacteria are prime movers that resolutely push their way through to other cells. As L. Mahadevan and Paul Matsudaira of the Massachusetts Institute of Technology explain, the engines in this case are springs or ratchets that are clusters of molecules, rather than single proteins like myosin and kinesin. Researchers don’t yet fully understand these engines’ fueling process or the details of how they move, but the result is a force to be reckoned with. For example, one such engine is a spring-like stalk connecting a single-celled organism called a vorticellid to the leaf fragment it calls home. When exposed to calcium, the spring contracts, yanking the vorticellid down at speeds approaching three inches (eight centimetres) per second.Springs like this are coiled bundles of filaments that expand or contract in response to chemical cues. A wave of positively charged calcium ions, for example, neutralizes the negative charges that keep the filaments extended. Some sperm use spring-like engines made of actin filaments to shoot out a barb that penetrates the layers that surround an egg. And certain viruses use a similar apparatus to shoot their DNA into the host’s cell. Ratchets are also useful for moving whole cells, including some other sperm and pathogens. These engines are filaments that simply grow at one end, attracting chemical building blocks from nearby. Because the other end is anchored in place, the growing end pushes against any barrier that gets in its way.Both springs and ratchets are made up of small units that each move just slightly, but collectively produce a powerful movement. Ultimately, Mahadevan and Matsudaira hope to better understand just how these particles create an effect that seems to be so much more than the sum of its parts. Might such an understanding provide inspiration for ways to power artificial nano-sized devices in the future? “The short answer is absolutely,” says Mahadevan. “Biology has had a lot more time to evolve enormous richness in design for different organisms. Hopefully, studying these structures will not only improve our understanding of the biological world, it will also enable us to copy them, take apart their components and recreate them for other purpose.”According to the author, research on the power source of movement in cells can contribute to
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MCQ->Read the following and answer the question based on it. Proteins are used by the body for energy, metabolism, gene growth and maintenance. 10 to 35 percent of the daily calorie intake should ideally consist of proteins. They are found in all cells of the body. Hair and nail are made up of a protein called keratin, having sulphur bonds. Curlier hair has more sulphur links. Too much intake of proteins can sometimes lead to body weight. Proteins ................
MCQ-> Read the following passage and answer the questions. Passage: A new paper published by Rochman and her colleagues in February, in the journal Ecology, sifts through past research on marine debris to assess the true extent of the environmental threat. Plenty of studies have sounded alarm bells about the state of marine debris: Rochman and her colleagues set out to determine how many of those perceived risks are real Often. Rochman says, scientists will wrap up a paper by speculating about the broader impacts of what they've found. Maybe their study has shown that certain seabirds eat plastic bags, for example, and the paper goes on to warn that whole bird populations are at risk of dying out. "But the truth was that nobody had yet tested those perceived threats." Rochman says. "There wasn't a lot of information." Rochman and her colleagues examined more than a hundred papers on the impacts of marine debris that were published through 2013. Within each paper. they asked what threats scientists had studied-366 perceived threats in all and what they'd actually found. In 83 percent of cases, the perceived dangers of ocean trash were proven true. In most of the remaining cases. the working group found the studies too shoddy to draw conclusions from—they lacked a control group, for example. or used faulty statistics. Strikingly. Rochman says, only one well-designed study failed to find the effect it was looking for, an investigation of mussels ingesting microscopic plastic bits. The plastic moved from the mussels' stomachs to their bloodstreams. scientists found. and stayed there for weeks—but didn't seem to stress out the shellfish. A lot of ocean debris is "microplastic," or pieces smaller than five millimetres. These may be the beads from a facial scrub. fibres shed by synthetic clothing in the wash. or eroded remnants of larger debris. Compared to the number of studies investigating large-scale debris. Roclunan's group found little research on the effects of these tiny bits. There are also, she adds, a lot of open questions about the ways that ocean debris can lead to sea-creature death. Many studies have looked at how plastic affects an individual animal or that animal's tissues or cells, rather than whole populations. And in the lab, scientists often use higher concentrations of plastic than what's really in the ocean. None of that tells us how many birds or fish or sea turtles could die form plastic pollution or how deaths in one species could affect that animal's predators, or the rest of the ecosystem. "We need to be asking more ecologically relevant questions." Rothman says. Usually, scientists don't know how disasters like oil spills or nuclear meltdowns will affect the environment until after they've happened. she says. "We don't ask the right questions early enough." But if ecologists can understand how the slow-moving disaster of ocean garbage is affecting ecosystems. they might be able to prevent things from getting worse.Which ONE of the following conclusions based on the examination of the hundred-odd papers on marine debris and its ecological impact by Rachman and her colleagues is NOT CORRECT?
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MCQ-> Answer question based on the following information:Mrs. Sharma has a house which she wants to convert to a hostel and rent it out to students of a nearby women’s college. The house is a two story building and each floor has eight rooms. When one looks from the outside, three rooms are found facing North, three found facing East, three found facing West and three found facing South. Expecting a certain number of students, Mrs. Sharma wanted to follow certain rules while giving the sixteen rooms on rent:All sixteen rooms must be occupied.No room can be occupied by more than three students.Six rooms facing north is called north wing. Similarly six rooms facing east, west and south are called as east wing, west wing and south wing. Each corner room would be in more than one wing. Each of the wings must have exactly 11 students. The first floor must have twice as many students as the ground floor.However Mrs. Sharma found that three fewer students have come to rent the rooms. Still. Mrs.Sharma could manage to allocate the rooms according to the rules.How many students turned up for renting the rooms?
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